Studies on amine metabolism in the brain and effects of psychomimetic drugs. by Ian Leslie Martin

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Published by University of Birmingham in Birmingham .

Written in English

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Thesis (Ph.D.)-University of Birmingham, Department of Pharmacology - preclinical.

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Open LibraryOL20855957M

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If so, this would provide some biological link between psychoactive drugs, their effects upon amine metabolism and conditions which give rise to the need for such drugs. Perhaps, if endogenous amine mechanisms are chemically or genetically impaired, this could be reflected in altered psychophysiologic function in the face of excessive activation or by: Some studies of the effects of chlorpromazine, reserpine and dihydroxyphenylalanine on the concentrations of homovanillic acid, 3,4-dihydroxyphenylacetic acid and 5-hydroxyindolylacetic acid in ventricular cerebrospinal fluid of the dog using the technique of serial sampling of the cerebrospinal by: 7.

This is the first study to show that localized metabolism of a centrally active drug in the brain can alter its pharmacological effect. We manipulated the activity of rat brain CYP2B by local enzyme inhibition or induction, which increased or decreased propofol-induced sleep times by: This chapter describes the hallucinogenic amines and schizophrenia.

It also discusses the effect of hallucinogenic drugs. Radioactive N,N-dimethyltryptamine and some of its basic metabolites penetrate the blood brain barrier in mice and reach high levels in the first 10 min, the neocortex showing larger quantities than others.

The tranylcypromine isomers are both more sensitive towards dopamine than 5-hydroxytrypt- amine oxidation, the (+) isomer being the more effective of the two. These results are discussed in terms of the in vivo action of the drugs and their therapeutic by: BRAIN RESEARCH AMINE METABOLISM IN THE HUMAN BRAIN: FURTHER EVALUA- TION OF THE PROBENECID TEST J.

KORF AND H. VAN PRAAG Department of Biological Psychiatry, Groningen University, Groningen (The Netherlands) (Accepted June 2nd, ) INTRODUCTION Probenecid (p-[di-n-propylsulphamoyl]-benzoic acid, Benemid) inhibits the clearance of 5.

81 Metabolism of Biogenic Amines and Psychotropic Drug Effects in Schizophrenic Patients G. Neurologische Universitatsklinik unci Poliklinik, Hamburg 20 (Germany) During the last decade biochemical research in the field of mental illness was greatly stimulated by observations indicating that biogenic amines such as indoleamines and catecholamines may serve as neurotransmitters in brain.

Amine metabolism in brain. Ashcroft GW. Proceedings of the Royal Society of Medicine, 01 Nov62(11 Part 1): PMID: PMCID: PMC Free to read.

Share this article Share with email Share Some studies of the effects of chlorpromazine, reserpine and dihydroxyphenylalanine on the concentrations of homovanillic acid, 3.

1 In vitro models (synaptosones, electrically stimulated brain slices and monoamine oxidase (MAO) preparations have been used to identify the sites of action of nomifensine on brain monoamine metabolism.

2 Nomifensine potentiates neurotransmission in noradrenergic and dopaminergic synapses by blocking catecholamine uptake. Philip B. Bradley BSc (Hons), PhD, DSc, FIBiol, in Introduction to Neuropharmacology, Psychotomimetic drugs produce effects in normal, healthy subjects which resemble the symptoms of naturally occurring psychosis, e.g.

hallucinations and disturbances of thought, mood and behaviour, but which disappear when the effect of the drug wears off. They are also known as hallucinogenic or psychodelic drugs. Hypotheses relating alterations in central neurotransmitter amine systems to the pathophysiology of manic-depressive illness and schizophrenia have provided a driving force toward the study of alterations in amine metabolism in psychiatric patients; these theories are reviewed elsewhere in this volume and will not be represented here in detail.

Clement HW., Grote C., Wesemann W. () In vivo studies on the effect of monoamine oxidase inhibitors on dopamine and serotonin metabolism in rat brain areas. In: Riederer P., Youdim M.B.H. (eds) Amine Oxidases and Their Impact on Neurobiology.

Schubert J, Nybäck H, Sedvall G. Effect of antidepressant drugs on accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain. J Pharm Pharmacol.

Feb; 22 (2)– SMITH CB. EFFECTS OF D-AMPHETAMINE UPON BRAIN AMINE CONTENT AND LOCOMOTOR ACTIVITY OF MICE. J Pharmacol Exp Ther. Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4-alpha-dimethy1-meta-tyra-mine, Europ.

Pharmacol. Metabolism of psychoactive drugs directly in the brain may lead to local pharmacological modulation at the site of action and result in variable drug responses. The focus of our current study is the human CYP3A family members that contribute significantly to drug metabolism.

The effects of disulfiram (Antabuse) and ethanol (acting through its metabolite acetaldehyde) on amine metabolism may be understood in terms of this simulated model. It is shown that drugs that affect this system also cause alterations in the steady-state concentrations of the intermediate aldehydes and the possible implications of this are.

GLOWINSKI, J., AXELROD, J., & IVERSEN, L. Regional studies of catecholamines in the rat brain. Effects of drugs on the disposition and metabolism of H 3 norepinephrine and H 3 dopamine.

Journal of Pharmacology, Google Scholar. Amines participate in important metabolic and physiological functions in living organisms. Polyamines are essential for cell proliferation, growth, renewal, and metabolism. They are involved in nearly every step of DNA, RNA, and protein synthesis, and regulate the permeability and stability of cellular membranes.

Start studying Physiological Psychology Chapter 6 How do drugs and hormones influence the brain and behavior?. Learn vocabulary, terms, and more with flashcards, games, and other study tools. • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market Author Bios Li Di is an associate research fellow in the Pharmacokinetics, Dynamics, and Drug Metabolism Department at Pfizer Global Research and Development and has extensive experience in the pharmaceutical industry.

REDUCTIVE METABOLISM OF ALIPHATIC TERTIARY AMINE N-OXIDES by Pamela Tien BSc (HONS), MSc An HPLC analytical method was developed to study the metabolism of lignocaine N-oxide. The rapid and sensitive analysis of lignocaine and its metabolites The effect of cobalt on haem oxygenase and cytochrome P ALIPHA TIC TERTIARY AMINE.

The bicyclics are referred to as secondary amines because they contain two amine substitutions on the nitrogen in the chemical structure. Secondary amines mainly increase brain levels of norepinephrine more than serotonin, while the tertiary amines increase brain levels of serotonin more than epinephrine.

All of these are correct. Suggested Citation:"Metabolism of Aromatic Amines."National Research Council. Aromatic Amines: An Assessment of the Biological and Environmental gton, DC: The National Academies Press. doi: / Metabolism of Amines.

I duction represented secondary amine. The primary amine was assumed to be the difference between the total amines and the sum of secondary and tertiary amines. This method of estimating the primary amine was different from the procedure of Weber and.

Drugs in Psychiatric Practice present a comprehensive examination of the drug treatment in psychiatry. It discusses certain ways in which drugs behaved. It addresses the advances in pharmacology and the basis of prescription. Some of the topics covered in the book are the classification of psychotropic drugs; basic principles of pharmacokinetics and drug metabolism; anti-schizophrenic drugs.

The book gives more details on the actions of various biological amines on single neurons in the limbic system of the brain. The text also evaluates the use of hallucinogenic drugs in considering their heuristic value in the study of the biochemical basis of mental function.

Specialist in the study of the harmful effects of drugs on the body is. Toxicologist. Agent given to counteract harmful effects of a drug is an who studies the properties, uses and side effects of drugs is. Pharmacologist.

Reference book listing drug products is. Physician's Desk Reference (membranes around the spinal cord or brain. Metabolism of amines in the brain: proceedings of the symposium of the British and Scandinavian Pharmacological Societies, Edinburgh, July.

Amine neurotransmitters are found in many areas of the brain, and are important in controlling many aspects of mood and behavior; it has been suggested that the primary problem in depression is an increased sensitivity to receptors that are located on the presynaptic terminals of amine synapses.

This study evaluated whether the oral administration of haloperidol 5 mg would block the effects of an intravenous ketamine infusion (bolus of mg/kg followed by mg/kg per hour).

for determination of drugs and their metabolites and are also best suited for high throughput analysis. However, in LC-MS/MS assays, matrix effect and selection of suitable internal standards should be adequately addressed.

Background of drug metabolism The study of the metabolic fate of drugs is an essential and important part of the drug. The effects of MEA on the peripheral plasma catechol amine level and adrenal ascorbic acid content of rats were determined at 10, 30, and 60 min following intraperitoneal injections of mg/kg MEA.

An increase of plasma epinephrine concentration occurred 10 minutes after administration of MEA and the elevation persisted throughout the 1-hr. most of these drugs (P/P/H) gain their reinforcing values because of their ability to _____ rather than exerting effects on the primary reward centers if the brain Governmental Restraints research on P/P/Hs has been limited due to ________ ____ and lack of funding for this type of research.

brain and their effects are not well studied. They may be responsible for psychomimetic and dys-Fig Structure of morphine. at the initial “morphine receptor” or “mu receptors” and are therefore considered “mu agonists.” The usual pharmacokinetic parameters. The metabolism of tertiary amines. Janine Rose.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California Search for more papers by this author.

Neal Castagnoli Jr. Department of Pharmaceutical Chemistry, University of California, San Francisco, California @article{osti_, title = {Positron emission tomography assessment of effects of benzodiazepines on regional glucose metabolic rate in patients with anxiety disorder}, author = {Buchsbaum, M S and Wu, J and Haier, R and Hazlett, E and Ball, R and Katz, M and Sokolski, K and Lagunas-Solar, M and Langer, D}, abstractNote = {Patients with generalized anxiety disorder (n = 18) entered a   Clinical studies consistently demonstrate that a single sub-psychomimetic dose of ketamine, an ionotropic glutamatergic NMDAR (N-methyl-D.

PHARMACOKINETICS LECTURE NOTES JAN/FEB 1 PHARMACOKINETICS Pharmacokinetic is the study of the movement of drugs in the body. Processes of Pharmacokinetics Slideshare uses cookies to improve functionality and performance, and to. Yet, these drugs produce a more consistent and greater reduction in amine metabolite concentrations than that reported to occur in depressed patients.

In light of this, it is suggested that the depletion of brain norepinephrine and dopamine, or serotonin, is, in itself, not sufficient to account for clinical depression.

Drugs that induce cytochrome P activity may reduce the availability of some protease inhibitors by increasing first pass metabolism. 0 degrading of proteins and nucleic acid, biogenic amine metabolism and is necessary for RNA chain initiation.

Tandamine is a selective norepinephrine reuptake inhibitor with a tricyclic structure. [1] [2] [3] It was developed in the s as an antidepressant but was never commercialized.

[1] [2] [3] Tandamine is analogous to pirandamine, which, instead, acts as a selective serotonin reuptake inhibitor (SSRI).The possible role of hydroxylamine and imine intermediates in the metabolism of amphetamine and related primary amines is discussed.

The inherent instability of imines, has hitherto precluded the recognition of these compounds as metabolites of primary [email protected]{osti_, title = {Effects of phenylethanolamine N-methyltransferase inhibitors on uptake and release of norepinephrine and dopamine from rat brain}, author = {Liang, N Y and Hower, J A and Borchardt, R T}, abstractNote = {Inhibitors of phenylethanolamine N-methyltransferase (PNMT) and amphetamine were evaluated for their effects on the uptake of (TH)-norepinephrine (TH-NE) and.

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