MicroRNAs biology, function & expression

Cover of: MicroRNAs |

Published by DNA Press in Eagleville, PA .

Written in English

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Edition Notes

Book details

StatementNeil J. Clarke, Philippe Sanseau, editors.
Classifications
LC ClassificationsQP
The Physical Object
Pagination384 p. :
Number of Pages384
ID Numbers
Open LibraryOL22762097M
ISBN 109781933255194

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MicroRNAs (miRNAs) represent a class of small, to nucleotide-long, noncoding RNA molecules. Until now, members of the family were identified in humans. Their major role is in the posttranscriptional regulation of protein expression, and their involvement was demonstrated in normal and in pathological cellular processes.

miRNAs can be described as “multivalent,” with one miRNA. MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field.

MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening MicroRNAs book the emerging field of microRNAs and their relevance to chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field.

First identified a decade ago, microRNAs (miRNAs) are small, noncoding RNA molecules that appear to regulate gene expression. Found in plant and animal species and possibly traceable back to ancient forms of life, miRNAs are now estimated to regulate a third or more of MicroRNAs book genes.2/5(1).

MicroRNAs are short MicroRNAs book RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many aspects of development, homeostasis and disease.

Endothelial cells are key regulators of different aspects of vascular biology including the formation of new blood vessels (angiogenesis).Cited by: MicroRNAs constitute a particularly important class of small RNAs given their abundance, broad phylogenetic conservation and strong regulatory effects, with plant miRNAs uniquely divulging their ancient evolutionary origins and their strong post-transcriptional regulatory effects.

In Plant. Book Description This wide-ranging reference work will be an invaluable resource for all those wishing to use miRNA techniques in their own research, both in academia and industry.

From their discovery, functions and detection to their role in disease biology, this volume uniquely integrates basic miRNA biology with future by: This book will be of immense help for researchers in the field of cancer research.” (Omer Iqbal, Doody’s Review Service, March, ) “Offers a compilation of reviews in the emerging field of microRNAs in cancer.

these reviews are concise and informative and provide a starting point to key aspects of this rapidly evolving field. Covering the full range of relevant concepts and giving a look into present and future possibilities, Mapping of Nervous MicroRNAs book Diseases via MicroRNAs is a necessary cutting-edge reference for neurologists, neuropathologists, and researchers and practitioners in a wide range of related fields.

1. Cell. Jan 23;(2) MicroRNAs: genomics, biogenesis, mechanism, and function. Bartel DP(1). Author information: (1)Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MAUSA.

[email protected] MicroRNAs (miRNAs) are endogenous approximately 22 nt RNAs that can play important regulatory roles in animals and plants by targeting Cited by:   The NOOK Book (eBook) of the microRNAs in Development by Elsevier Science at Barnes & Noble.

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Author: Elsevier Science. New York, NY, Ma – Since their discovery in the s, microRNAs have proven to play a complex role in normal and abnormal functioning of many organ systems. In the April issue of Translational Research, entitled “MicroRNAs: A Potential New Frontier for Medicine,” an international group of medical experts explores several themes related to our current understanding of.

Book description MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their discovery has revolutionised both basic biomedical research and drug by: From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions.

Providing a comprehensive account, this book also includes. MicroRNAs have critical roles in a number of serious diseases and, as a result, are of major interest as clinical diagnostic targets. Conventionally, microRNAs are collected from blood and urine samples and are measured by either quantitative reverse-transcription polymerase chain reaction or microarray.

Recently, nanopore sensing techniques have been applied for measuring microRNAs at the Cited by: 4. microRNAs in Toxicology and Medicine is a comprehensive and authoritative compilation of up-to-date developments in this emerging research area, presented by internationally recognized investigators.

It focuses on the role of microRNA in biology and Pages: The book “microRNAs in cancer” is an invaluable collection of the recent findings and reviews of leading experts about the current understanding of microRNAs roles in the development. Purchase MicroRNA in Regenerative Medicine - 1st Edition.

Print Book & E-Book. ISBNBook Edition: 1. Tomato (Solanum lycopersicum) is one of the most important crops around the world and also a model plant to study response to stress. High-throughput sequencing was used to analyse the microRNA (miRNA) profile of tomato plants undergoing five biotic and abiotic stress conditions (drought, heat, P.

syringae infection, B. cinerea infection, and herbivore insect attack with Leptinotarsa Cited by: 2. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as.

Vascular remodeling or arterial remodeling is a process of adaptive alteration of vascular wall architecture and leads to the endothelial cell (EC) dysfunction and synthetic or contractile phenotypic change of VSMCs, and the infiltration of monocytes and Macrophages that promotes vascular diseases including atherosclerosis.

Recent findings have demonstrated that microRNAs (miRNAs) are involved Cited by: 1. This new volume in the Current topics in Developmental Biology series concentrates on MicroRNAs in Development. It includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA.

With an international team of authors, this volume is a must-have addition for researchers and students trates on microRNAs in. MicroRNAs (miRNAs) are a family of 21–nucleotide small RNAs that, at least for those few that have characterized targets, negatively regulate gene expression at Cited by: MicroRNAs in Cancer - CRC Press Book.

The book explores the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It reviews their potential for applications in cancer diagnosis, prognosis, and therapeutic targets. In addition it discusses the potential use in translational medicine.

The book groups 38 chapters into six major sections that cover the discovery of microRNAs, their functions, detection, and quantitation, bioinformatics approaches to discover new microRNA targets, and finally their implication in stem cell biology, development, and : Marc R.

Fabian, Thomas F. Duchaine. Jazdzewski, K. et al. Polymorphic mature microRNAs from passenger strand of pre-miRa contribute to thyroid cancer. Proc. Natl Acad. Sci. USA– ().Cited by: Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state.

It has been demonstrated that miRNAs play a momentous role in oncogenesis via regulating cell proliferation and apoptosis as oncogenes or tumour suppressors. MicroRNA definition is - a short segment of RNA that suppresses gene expression by binding to complementary segments of messenger RNA and interfering with the formation of proteins by translation —called also miRNA.

How to use microRNA in a sentence. ISBN: OCLC Number: Description: viii, pages: illustrations ; 24 cm: Contents: 1. Breast cancer MicroRNAs: signaling networks and clinical applications / Gabriel Eades, Yuan Yao and Qun Zhou MicroRNAs in breast cancer development / Mei Yang [and others] MicroRNAs controlling invasion and metastasis in breast cancer / Cšar Lp̤ez-Camarillo.

A Brief Review on the Mechanisms of miRNA Regulation Article Literature Review (PDF Available) in Genomics Proteomics & Bioinformatics 7(4) December with 3, Reads.

MicroRNAs are a family of small, non-coding RNAs that regulate gene expression in a sequence-specific manner.

The two founding members of the microRNA family were originally identified in Caenorhabditis elegans as genes that were required for the timed regulation of developmental events.

Since then, hundreds of microRNAs have been identified. MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers. Takahiro Ochiya and Ryou-u Takahashi (Eds.) Pages: Published: October (This book is a printed edition of the Special Issue MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers that was published in JCM) Download PDF.

MicroRNAs (miRNAs) are genomically-encoded, untranslated RNA molecules of approximately nucleotides (nt). MiRNAs regulate diverse processes such as cell fate specification, apoptosis, and metabolism (Bartel, ).In a few short years, these tiny RNAs have impacted virtually every field of biology and changed the way we view gene regulation.

MicroRNAs (or miRNAs) comprise a novel class of small, non-coding endogenous RNAs that regulate gene expression by directing their target mRNAs for degradation or translational repression. About this book Introduction It not only expertly describes the molecular mechanisms underlying the malignant transformation process but also compiles cutting-edge research on microRNAs in several forms of cancer, including colorectal cancer, pancreatic cancer, leukemia/lymphoma, prostate cancer, lung cancer, ovarian cancer, and bone cancer.

MicroRNAs in the Rhizobia Legume Symbiosis Stacey A. Simon, Blake C. Meyers, D. Janine Sherrier Plant Physiology Nov(3) ; DOI: /ppCited by: Micro RNAs are small non-coding regions of RNA (usually of around 21 nucleotides in length) that are involved in the regulation of gene expression by the silencing of genes.

This occurs through a process called RNA interference (RNAi).Micro RNA base pairs with mRNA by its 5' to the 3'-untranslated region of mRNA to prevent translation of the mRNA strand, resulting in the prevention of protein.

MicroRNAs (miRNAs) are small, noncoding RNAs transcribed from DNA that are 18–24 nucleotides in length. A single miRNA has the capacity to regulate a large number of target messenger RNAs (mRNAs), and the main function of miRNAs is to downregulate gene expression.

A large set of miRNAs is overexpressed or downregulated in various human cancers compared with normal tissues, and gene Cited by: 1. Mapping of Nervous System Diseases via MicroRNAs (Frontiers In Neurotherapeutics Ser.

#2) View larger image. By: Christian Barbato and Francesca Ruberti. microRNA: Cancer is an ideal companion to both microRNA: Basic Science andmicroRNA: Medical Evidence. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical : Springer International Publishing.

"This is an excellent book with good illustrations on circulating microRNAs, given their pathogenic, diagnostic, and potential therapeutic relevance. The intended audience includes students, researchers, and others in the field of biomedicine wishing to learn more about microRNAs.Individual microRNAs are named with the prefix “mir” and a number, like mir-1 or mir In humans, over 2, different microRNAs have been identified since the discovery of microRNAs 20 years ago.

MicroRNAs as Biomarkers The action of microRNAs in the body can regulate almost every kind of biological process imaginable, for example.MicroRNA publishes letters, full-length/ mini reviews, research articles, drug clinical trial studies and thematic issues on all aspects of microRNA (miRNA) research.

The scope of the journal covers all experimental miRNA research and applied research in health and disease, including therapeutic, biomarkers, and diagnostic applications of MiRNA.

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